日誌
肺動脈高壓怎麼治？Part-III(缺鎂、鋅、維它命C、D、E，可以補充桂格完膳) ... ... ...
肺動脈高壓怎麼治？Part-II(建議喝紅茶)
提到：
缺氧時會造成肺動脈壓上升
血管內皮細胞和肺動脈平滑肌細胞(pulmonary arterial smooth muscle cell，paSMC)
的增生和肥大是肺動脈高壓(pulmonary hypertension，PH)的特徵。
An increase in cytosolic Ca(2+) concentration ([Ca(2+)]cyt)
in pulmonary arterial smooth muscle cells (PASMC) is a major trigger
for pulmonary vasoconstriction and an important stimulus
for pulmonary arterial medial hypertrophy in patients
with idiopathic pulmonary arterial hypertension (IPAH).
肺動脈平滑肌細胞（PASMC）中細胞溶質Ca（2+）濃度（[Ca（2 +）] cyt）的增加
是肺血管收縮的主要誘因，是特發性肺動脈高血壓（IPAH）病患者肺動脈內側肥大的重要刺激因素。
Magnesium relaxes arterial smooth muscle by decreasing intracellular Ca2+
without changing intracellular Mg2+.
鎂通過減少細胞內Ca2 +而不改變細胞內Mg2 +來放鬆動脈平滑肌。
所以
肺動脈平滑肌細胞肥大應該缺鎂
另外
細胞溶質Ca（2+）濃度
的增加可能也缺少維它命D
Hyperparathyroidism secondary to vitamin D deficiency may has a role in higher
pulmonary arterial pressure and might be a relationship between pulmonary hypertension
and vitamin D deficiency
肺動脈高血壓可能和維生素D缺乏有關
肺動脈平滑肌細胞（PASMC）
In summary, the data from this study indicate that increased Cu transportation
due to upregulated CTR1 and ATP7A in pulmonary arteries and PASMC
contributes to the development of hypoxia-induced pulmonary hypertension.
總之，該研究的數據表明，由於肺動脈和PASMC中上調的CTR1和ATP7A導致的銅轉運增加
有助於缺氧誘導的肺動脈高壓的發展。
節錄自https://www.ncbi.nlm.nih.gov/pubmed/24614111
These data suggest that the inhibition of endothelial cell proliferation
by a copper-restricting strategy could be explored as a new
therapeutic approach in pulmonary arterial hypertension.
這些數據表明，通過銅限制策略抑制內皮細胞增殖可以作為探索肺動脈高壓的新治療方法。
雖然銅在人體有負的一面，但還是有正面的作用，所以得要找出
缺氧及
抑制內皮細胞增殖的應對方法
VEGF has been shown to regulate endothelial cell (EC) proliferation and migration.
已顯示VEGF調節內皮細胞（EC）增殖和遷移。
Vascular endothelial cell growth factor (VEGF) stimulates endothelial cell (EC)
proliferation and migration
血管內皮細胞生長因子（VEGF）刺激內皮細胞（EC）增殖和遷移
Pulmonary arterial hypertension (PAH) is a proliferative vasculopathy characterized
by high circulating CD34+CD133+ proangiogenic progenitors,
and endothelial cells that have pathologic expression
of hypoxia-inducible factor 1 α (HIF-1α).
肺動脈高壓（PAH）是一種增殖性血管病變，其特徵在於高循環CD34 + CD133 +
促血管生成祖細胞，以及具有缺氧誘導因子1α（HIF-1α）病理表達的內皮細胞。
HIF-1α啟動眾多下游的缺氧反應基因，例如：血管內皮細胞生長因子 (VEGF )
鋅、維它命C、D、E抑制或下調HIF-1α
鎂、維它命C、D、E降低或下調VEGF
總結以上：
建議主要以鎂、鋅治療肺動脈高壓，維它命C、D、E輔助。
補充鎂+鋅+維它命C+D+E，建議可以參考桂格完膳。
其它含鎂、鋅、維它命C、D、E高的食物http://blog.eyny.com/blog-5788411-762615.html
