In this study we determined the antiproliferative effects of interferon gamma
(IFNγ) on the glioblastoma cell lines T98G, SNB-19 and U-373,
focusing on the ability of IFNγ to increase levels of p21WAF1/CIP1,
an important negative regulator of cell cycle events.
在這項研究中,我們確定了干擾素γ(IFNγ)對膠質母細胞瘤細胞系T98G,
SNB-19和U-373的抗增殖作用,重點是IFNγ增加p21WAF1 / CIP1水平的能力,
p21WAF1 / CIP1是細胞週期事件的重要負調節因子。
IFNγ was found to inhibit the growth of all cell lines,
with inhibition ranging from 82.2% to 45.4%.
發現IFNγ抑制所有細胞系的生長,抑制範圍為82.2%至45.4%。
These results show that IFNγ has significant antiproliferative effects
on the glioblastoma cell lines
這些結果表明IFNγ對膠質母細胞瘤細胞系具有顯著的抗增殖作用
Inhibitory Effects of IFN-γ and Acyclovir on the Glioblastoma Cell Cycle
IFN-γ對膠質母細胞瘤細胞週期的抑制作用
At the cellular level, ACV and IFN-γ
inhibited the cell cycle in both the G1 and S phases.
在細胞水平,IFN-γ抑制細胞週期的G1期和S期。
Increase in PGE2 biosynthesis induces a Bax dependent apoptosis
correlated to patients’ survival in glioblastoma multiforme
與多形性膠質母細胞瘤患者存活相關的Bax依賴性細胞凋亡
PGE2 downstream of cyclooxygenase 2 (COX-2)
環加氧酶2(COX-2)下游的PGE2
Bax Activation Blocks Self-Renewal and Induces Apoptosis of
Human Glioblastoma Stem Cells.
Bax激活阻斷自我更新並誘導人膠質母細胞瘤幹細胞凋亡。
二、腦膜瘤(malignant meningioma)
However, it is suggested that reduced expression of Bax protein
is necessary for the malignant transformation and progression
of the brain tumors, since no histologically malignant
brain tumors with positive Bax protein were present.
然而,由於沒有存在具有陽性Bax蛋白的組織學惡性腦腫瘤,
因此表明Bax蛋白的表達降低對於腦腫瘤的惡性轉化和進展是必需的。
Dose-dependent of meningioma cell viability by celecoxib was seen in vitro
in both a malignant cell line (IOMM-Lee) and in six benign cell lines.
In this malignant IOMM-Lee cell line,this correlated with elimination of COX-2
enzymatic activity and a 51% reduction in prostaglandin E2(PGE2) levels,as well as
apoptosis.
在這種惡性IOMM-Lee細胞系中,消除COX-2
酶活性和前列腺素E2(PGE2)水平降低51%,與
細胞凋亡相關。
IL-4抑制COX-2表達和PGE(2)產生
Meningiomas are tumors arising from aracnoid layer cells and make up 20%
of all intracranial tumours.
腦膜瘤是由類囊體層細胞產生的腫瘤,佔所有顱內腫瘤的20%。
The expression analysis by microarray identified 4 genes with
significant decreased expression (BAD, BAX, FOS and TNFRSF25)
微陣列表達分析鑑定4個基因表達顯著下降(BAD,BAX,FOS和TNFRSF25)
MicroRNA-224 targets ERG2 and contributes to malignant progressions
of meningioma.
MicroRNA-224靶向ERG2對腦膜瘤的惡性進展。
Our results indicated that downregulation of miR-224 suppressed
cell growth and resulted in the enhancement of cell apoptosis
through activation of the ERG2-BAK-induced apoptosis pathway.
我們的研究結果表明,miR-224的下調抑制了細胞生長,
並通過激活ERG2-BAK誘導的細胞凋亡途徑導致細胞凋亡的增強。
IFN-γ直接誘導促凋亡蛋白BAK
三、星狀細胞瘤(Astrocytoma)
These results collectively suggest that caspase-1,
along with caspases-3 and -8, mediate Fas-induced
cell death in human astrocytoma cells
這些結果共同表明caspase-1與caspase-3和-8一起介導
人星形細胞瘤細胞中Fas誘導的細胞死亡
干擾素γ誘導caspases-1,-3,-8的上調產生細胞凋亡
人類低級星形細胞瘤細胞表達IL-4受體並且其生長被IL-4阻滯
IL-4和促凋亡蛋白Bax有關,Bax導致細胞通過caspase-3凋亡。
四、髓母細胞瘤(medulloblastoma)
關於
髓母細胞瘤(medulloblastoma):Bax依賴性細胞凋亡
IL-4和促凋亡蛋白Bax有關,Bax導致細胞通過caspase-3凋亡。
We have generated a mouse model system with a high incidence of medulloblastoma
, a malignant neoplasm believed to arise from immature precursors
of cerebellar granule neurons.
產生了一種髓母細胞瘤的發病率很高的模型系統,
一種被認為是由小腦顆粒神經元的未成熟前體引起的惡性腫瘤。
The tumors that occur in the continued presence of IFN-gamma display
extensive necrosis and apoptosis as well as macrophage and
lymphocytic infiltration
在持續存在IFN-γ的情況下發生的腫瘤顯示出廣泛的壞死和凋亡
Medulloblastoma, a primitive neuro-ectodermal tumor that arises in
the posterior fossa, is the most common malignant brain tumor
occurring in childhood.
髓母細胞瘤是一種原始的神經外胚層腫瘤,起源於後顱窩,是兒童時期最常見的惡性腦腫瘤。
high-dose chemotherapy followed by autologous stem cell transplantation (HSCT)
高劑量化療隨後進行自體幹細胞移植(HSCT)
Already before HSCT, survivors showed higher IFNγ levels in sera
as well as higher numbers of IFNγ-positive T-cells.
在HSCT之前,倖存者在血清中顯示出更高的IFNγ水平以及更高數量的IFNγ陽性T細胞。
After transplantation, this effect was even more pronounced.
移植後,這種效果更加明顯。
上述的意思是髓母細胞瘤的倖存者是因為血清中顯示出
更高的IFNγ水平以及更高數量的IFNγ陽性T細胞。
總結以上:
一、二、三、四均與
全套治療所有癌症的食材參考Part-IX(治療癌症食療的全貌逐漸明朗邁向尾聲~~~)
所提
干擾素-γ和IL-4或所涉及之促凋亡蛋白Bak、Bax及凋亡蛋白酶(caspases)相關
建議採用以下營養對抗腦癌
能提高IL-4的元素:鋅、維生素A、兒茶素、茄紅素、薑黃素、黃酮類化合物(蜂膠黃酮、生物類黃酮、大豆異黃酮)、鞣花酸
能提高IFN-γ的元素:鋅、硒、錳、維生素C、高劑量維生素E、茄紅素、大豆異黃酮、蜂膠黃酮、多醣體