日誌

病毒感染，吃這些消滅病毒！Part-II

已有 926 次閱讀2016-11-9 09:12 PM

免疫球蛋白G可分為四種亞群：免疫球蛋白G1、G2、G3、G4。免疫球蛋白G1、G3(IgG1、IgG3)主要對抗蛋白質抗原，如常見的病毒感染等。

節錄自http://www.mmh.org.tw/taitam/pedia/encyclopedia/book8-1.htm

Interleukin (IL)-10 has been shown to have various effects on B cells, including positively affecting the production of immunoglobulin A (IgA) and IgG

已經顯示白細胞介素（IL）-10對B細胞具有各種作用，包括積極影響免疫球蛋白A（IgA）和IgG的產生

節錄自https://www.ncbi.nlm.nih.gov/pubmed/16784489

interleukin 10 (IL-10) could stimulate IgG1 and IgG3 secretion by human CD40-activated naive (slgD +) tonsillar B cells.

白細胞介素10（IL-10）可以刺激B細胞的IgG1和IgG3分泌。

節錄自http://jem.rupress.org/content/jem/183/3/937.full.pdf

褪黑激素特異性增強抗原特異性IgG1抗體的分泌並降低IgG2a同種型的產量。

褪黑素增加IL-4的產生並抑制IL-2和IFN-γ的分泌

詳見https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1904848/

IgG1產生依賴於T細胞幫助和IL-4

詳見https://www.ncbi.nlm.nih.gov/pubmed/11884434

IgG1由Th2，IL-4-細胞因子支持產生

詳見https://arthritis-research.biomedcentral.com/articles/10.1186/ar383

IL-4可以產生IgG1、IgE、hIgE、hIgG4；抑制IgG2a、IgG2b、IgG3、IgM產生。

IL-10可以產生IgM、IgG、hIgG1、hIgG3

IL-13可以產生IgM、IgG全部、hIgE、hIgG4

IFN-γ可以產生IgG2a、IgG3；抑制IgG1、IgG2b、IgE產生。

詳見https://books.google.com.tw/books?id=U86r3ZkLi58C&pg=PA42&lpg=PA42&dq=IgG3+IL

Exogenous IL-2 and IL-10 or IL-10 and TGF- β led to the production of specific IgG3 or IgG1 and/or IgA, respectively.

外源IL-2和IL-10或IL-10和TGF-β分別導致產生特異性IgG3或IgG1和/或IgA。

節錄自http://onlinelibrary.wiley.com/doi/10.1046/j.1365-3024.2003.00603.x/pdf

能提高IL-4的元素：

鎂、鋅、硒、鈣、維生素A、維生素C、維生素D、兒茶素、花青素、茄紅素、薑黃素、黃酮類化合物(生物類黃酮、大豆異黃酮)、鞣花酸

節錄自http://blog.eyny.com/blog-5788411-749855.html

In placenta, selenium pre-treatment significantly increased IL4 and IL13 mRNA expression

在胎盤中，硒預處理顯著增加了 IL4 和 IL13 mRNA 的表達

節錄自https://ap-st01.ext.exlibrisgroup.com/61USC_INST/upload/1676166328921/Selenium%20Prevents%20Inflammation%20in%20Human%20Placenta%20and%20Adipose%20Tissue%20In%20Vitro%20-%20Implications%20for%20Metabolic%20Diseases%20of%20Pregnancy%20Associated%20with%20Inflammation.pdf?Expires=1676166449&Signature=kU0qGhY9I~ulF9rNTxT4-xivcjX41E4paITZXWXjqQ4lRHF~K3QH~6mi6oaaC6vtwrgDtlj6UuEFvycqqNTQLLm1yENlC01nU1XXepFDr0zyBHEYbVkR2UDcefdHSZc3d32hJPLJCh7YA09zWfO4kKuU1jHPWJ9LUWs3IucqLpAWqpz-8yQJsPI1Jt2iOILwGlSBT6bnc-WL16-WmnZlCechUkzFSFE8Eo1Kca8-qONEFJMUYxUmHz-K8VccJmmXDb0AFEVj0r~dnqZs6KaOtu5O6Ln8PzKsGAbZDLrx~wXHL8bVtZTvg~OKAchSNu1spy2BbpK5PODODPMid~KlUg__&Key-Pair-Id=APKAJ72OZCZ36VGVASIA

Higher serum vitamin D levels positively correlated with higher ratios of IL-4+IL-10/IL-17A+TNF-α (r= 0.37, P <0.01)

較高的血清維生素 D 水平與較高的 IL-4+IL-10/IL-17A+TNF-α 比率正相關 (r= 0.37, P <0.01)

節錄自https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808893/

intracellular Ca2+ concentration ([Ca2+]i)

細胞內Ca2 +濃度（[Ca2 +] i）

The production of IL-4 requires elevation of [Ca2+]i

IL-4的產生需要升高[Ca2 +] i

節錄自https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2744309/

增加線粒體Ca2 +的水平可用於延長效應CD4細胞中IL-4的表達。

節錄自http://www.eyny.com/blog-5788411-772601.html

the TH2 products IL-4, -6 and -10 remain unchanged during zinc deficiency

在鋅缺乏期間，TH2產物IL-4，-6和-10保持不變(那是因為有可能還有別的營養幫助維持IL-4，IL-10的產量)

節錄自http://jn.nutrition.org/content/133/5/1452S.long

No significant correlation was found between vitamin D and IL-4 levels in the patients of both groups.

兩組患者維生素D和IL-4水平無明顯相關性。

節錄自http://heartdiseases.conferenceseries.com/abstract/2016/an-association-of-serum-vitamin-d-il-4-level-and-vdr-gene-polymorphism-in-cad-with-and-without-t2dm

AA( Allergic Asthma)
AR(Allergic Rhinitis)
AA（過敏性哮喘）
AR（過敏性鼻炎）
Mean serum selenium level of asthmatic (84 ± 11 µg/L) and rhinitis (82 ±10 µg/L) groups was significantly lower than control subjects (106 ± 11
µg/L): P<0.001 (Fig2).
哮喘（84±11μg/ L）和鼻炎（82±10μg/ L）組的平均血清硒水平均顯著低於對照組（106±11
μg/ L）：P <0.001（圖2）。
Mean serum IL-4 level of AA and AR groups was significantly higher than the
control group (1.0 ± 0.2 pg/ml), P<0.001 (Fig 3).
哮喘和鼻炎組的平均血清IL-4水平明顯高於對照組（1.0±0.2 pg / ml），P <0.001（圖3）。
節錄自http://iji.sums.ac.ir/article_16710_275232b3681d3bfa4e90926bdb60acbb.pdf
由此可見哮喘和鼻炎組是因為缺
硒，
IL-4水平才會明顯高於對照組；因此硒
會降低IL-4水平。
mRNA levels of Th2 cytokines such as IL-4 and IL-10 in the catechin-treated group were markedly enhanced compared with that of control group .
兒茶素治療組的Th2細胞因子如IL-4和IL-10的mRNA水平明顯高於對照組。
節錄自https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712737/
cord blood mononuclear cell (CBMC)
臍血單核細胞（CBMC）
Supplementation with vitamin C had no effect on CBMC proliferation,
but increased IFN-γ and IL-4 production.
補充維生素C對CBMC增殖沒有影響，但會增加IFN-γ和IL-4的產生。
節錄自https://www.ncbi.nlm.nih.gov/pubmed/24067384
鞏膜炎治療總整理(主要缺鎂鋅維它命AD，建議善存+多喝豆漿+多喝茶。)
http://www.eyny.com/blog-5788411-772679.html
告訴我們：
鎂處理誘導了更高濃度的抗炎細胞因子白介素IL-4和IL-10

~~~

1. A method of decreasing inflammation of a joint in a mammalian subject, the method comprising:
orally administering to the subject a composition comprising an active ingredient selected from the group consisting of ProC3G™, cyanidin-3-glucoside (C3G) or protocatechuic acid (PCA) or a combination thereof,
wherein said composition has the effect of decreasing levels of MMP1, TFG-beta, and MMP13 in the synovial fluid of the joint and increasing the levels of TIMP-1, VEGF, IL-10 and Il-4 in the synovial fluid of the joint to cause a reduction of inflammation in the joint.
向受試者口服施用包含選自ProC3G™、花青素-3-葡萄糖苷(C3G)或原兒茶酸(PCA)或其組合的活性成分的組合物，
其中所述組合物具有降低關節滑液中MMP1、TFG-β和MMP13水平並增加關節滑液中TIMP-1、VEGF、IL-10和IL-4水平的作用以減少關節的炎症。
節錄自https://www.mysciencework.com/patent/show/oral-administration-anthocyanins-anthocyanidins-metabolites-treatment-inflammation-inflammed-joint-US20160184341A1

能提高IL-10的元素：

鎂、鈣、鋅、錳、硒、維生素A、維生素D、維生素E、兒茶素、花青素、薑黃素、鐵、碘

詳見http://blog.eyny.com/blog-5788411-742022.html

茄紅素、黃酮類化合物(生物類黃酮、大豆異黃酮)、鞣花酸

節錄自http://blog.eyny.com/blog-5788411-749855.html

通過增加細胞內鈣水平來誘導白介素10表達

節錄自http://www.eyny.com/blog-5788411-772601.html

Zinc treatment enhanced IFN-γ & IL-10 concentrations in PHA-stimulated PBMC and IL-1β & TNF-α in LPS-stimulated cells, while zinc down-regulated levels of IL-1β & TNF-α in PBMC stimulated with superantigens.

鋅提升IFN-γ、IL-10的濃度，下調IL-1β、TNF-α等級。

節錄自https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407988/

鞣花酸上調IL-10

https://www.ncbi.nlm.nih.gov/pubmed/27240831

FIGURE 2.

Effect of selenium supplementation on T lymphocyte proliferation (A), interferon γ (IFN-γ) production (B), interleukin (IL) 10 production (C), and IL-2 production before and after polio vaccination.
圖2。
硒補充對脊髓灰質炎疫苗接種前後T淋巴細胞增殖（A），干擾素γ（IFN-γ）產生（B），白細胞介素（IL）10產生（C）和IL-2產生的影響。
A significant main effect of time was observed for T lymphocyte proliferation
(P < 0.001), IFN-γ production (P < 0.001), and IL-10 production (P < 0.001).
觀察到T淋巴細胞增殖的時間的顯著主要影響 （P <0.001），IFN-γ產生（P <0.001）和IL-10產生（P <0.001）。
節錄自http://ajcn.nutrition.org/content/80/1/154.full
鞏膜炎治療總整理(主要缺鎂鋅維它命AD，建議善存+多喝豆漿+多喝茶。)
http://www.eyny.com/blog-5788411-772679.html
告訴我們：
鎂處理誘導了更高濃度的抗炎細胞因子白介素IL-4和IL-10

能提高IL-2的元素：

鋅、銅、硒、鈣、維生素A、維生素C、維生素E、大豆異黃酮、兒茶素、花青素、茄紅素、多醣體、牛磺酸

詳見http://blog.eyny.com/blog-5788411-750432.html

Early calcium signaling and calcium requirements for the IL-2 receptor expression
and IL-2 production in stimulated lymphocytes.
刺激的淋巴細胞中IL-2受體表達和IL-2產生的早期鈣信號和鈣需求。
節錄自https://www.ncbi.nlm.nih.gov/pubmed/8912879

Vitamin A derivative, 9-cis retinal, increased TNF-alpha and IL-4 production in cultured mononuclear cells obtained from control and CVID patients.

維生素A衍生物9-順式視黃醛增加了TNF-alpha and IL-4 的產生

Vitamin A derivative, also, increased IL-2 and Il-4 production in cultured mononuclear cells obtained from CVID patients.

維生素A衍生物也增加了IL-2和IL-4的產生

節錄自https://www.ncbi.nlm.nih.gov/pubmed/15981093

Vitamin E supplementation increased production of IL-2 and IFN-γ in old mice

補充維生素E可增加老齡小鼠IL-2和IFN-γ的產生

節錄自https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2327029/

能提高IFN-γ的元素：

鋅、硒、錳、維生素A、維生素C(http://www.easydacom.com.tw/products.jsp?pclass=2&pid=85)、高劑量維生素E、兒茶素、茄紅素、大豆異黃酮、

多醣體(http://www.easydacom.com.tw/products.jsp?pclass=0&pid=2)

節錄自http://blog.eyny.com/blog-5788411-748850.html

(相關食物詳見連結網址)

Epigallocatechin-3-gallate (EGCG)

表沒食子兒茶素-3-沒食子酸酯（EGCG）

Here, we found that EGCG enhanced IFN-γ-induced signal transducer and activator of transcription 1 (STAT1) activation

在這裡，我們發現EGCG增強了IFN-γ誘導的信號轉導和轉錄激活因子1（STAT1）的激活。

節錄自https://pubmed.ncbi.nlm.nih.gov/25261409/

T cells collected from human subjects who had received oral zinc supplementation (15 mg/day) had higher expression of the activation marker IFN-gamma upon in vitro activation, indicating a potentiating effect of zinc on T cell activation.

從接受口服鋅補充（15mg /天）的人受試者收集的T細胞在體外激活時具有更高的活化標記IFN-γ表達，表明鋅對T細胞活化的增強作用。

節錄自https://www.ncbi.nlm.nih.gov/pubmed/19401385

vivo production of IFN-γ was negatively correlated to plasma Cu levels

IFN-γ的體內產生與血漿Cu水平呈負相關

In vitro, increased Cu levels inhibited IFN-γ production.

體外，增加的銅水平可抑制IFN-γ的產生。

節錄自https://bmcinfectdis.biomedcentral.com/articles/10.1186/1471-2334-4-50

Result showed that vitamin A improved cellular immune response characterized
by increasing levels of IL-12, IFN-γ and macrophage phagocytosis index.
結果表明，維生素A改善了細胞免疫反應，其特徵在於IL-12，IFN-γ和巨噬細胞吞噬指數增加。
節錄自https://aip.scitation.org/doi/10.1063/1.4953523

由以上看來

IL-10及IL-13不但能產生IgG1、IgG3

而且不會抑制其它Ig的產生

而由上方知道

IL-2除了可以產生特異性IgG3或IgG1

還可以上調IgG2的合成(詳見http://blog.eyny.com/blog-5788411-750594.html)

也許

IL-2也不會抑制其它Ig的產生

所以要產生對抗病毒的

建議參考
能提高IL-10、IL-2、IL-13的元素