colorectal cancer (CRC)
結直腸癌(CRC)
We found a significant decrease in the total mean serum Cu and Zn
concentrations in CRC patients as compared with the control group
(137.5 ± 122.38 vs. 160.68 ± 45.12 μg/dl and 81.04 ± 52.05
vs. 141.64 ± 51.75, respectively).
我們發現CRC患者的總平均血清Cu(銅)和Zn(鋅)濃度與對照組相比顯著降低
However, the serum Cu/Zn ratio in the patient group was
significantly higher than that measured in the control group (p = 0.00).
然而,患者組的血清Cu / Zn比率顯著高於對照組的血清Cu / Zn比率(p = 0.00)。
A report by Jaiswal and Narayan has also stated the mechanisms
by which zinc causes growth arrest in colon cancer cells.
Jaiswal和Narayan的報告還闡述了鋅導致結腸癌細胞生長停滯的機制。
Eluates were prepared by high salt extraction from normal colonic
mucosa and adenocarcinomatous tissue from 28 patients
通過從28名患者的正常結腸粘膜和腺癌組織中提取高鹽來製備洗脫液
IgA in 55% eluates from normal colon and 39% from carcinomas;
55%的IgA從正常結腸洗脫,39%從癌中洗脫;
IgM in 55% from normal colon and 37% from carcinomas.
IgM在正常結腸中佔55%,在癌中佔37%。
意思是說
腸癌細胞IgA及IgM數量較少
鋅和維生素A缺乏與IgA產生較低有關
IgA通過刺激巨噬細胞系的腫瘤壞死因子-α(TNF-α)產生和凋亡來抑制細胞生長。
An inverse association between Selenium supplementation and the risk
of colorectal cancer was observed in several studies (184-189).
在一些研究中觀察到硒補充與結腸直腸癌風險之間的反向關聯(184-189)。
Selenium supplementation by way of brewer’s yeast supplementation
was associated with up to 50% reduction in the incidence of
colorectal cancer (188,190).
通過啤酒酵母補充硒與結腸直腸癌發病率降低高達50%相關(188,190)。
glutathione peroxidase 1 (GPX1)
穀胱甘肽過氧化物酶1(GPX1)
We found significant differences in GPX1 expression between tumor
and normal tissues, with a 2-fold decrease in tumor tissues (p<0.05).
我們發現腫瘤和正常組織之間GPX1表達的顯著差異,腫瘤組織減少2倍(p <0.05)。
While selenium deficiency decreased mRNA levels by 60%, glutathione
peroxidase enzyme activity decreased by 93%
硒缺乏使mRNA水平降低60%,穀胱甘肽過氧化物酶活性降低93%
colorectal cancer (CRC)
結直腸癌(CRC)
The results indicated that compared with healthy controls,
patients with CRC showed lower concentrations of serum vitamin E
(WMD = −2.994 μmol/L, 95% CI = −4.395 to −1.593).
結果表明,與健康對照組相比,CRC患者血清維生素E濃度較低。
小結1:
由以上看來,大腸癌患者缺鎂、鋅、硒、維它命A、E。
It is aimed through this study to evaluate the transcript levels
of Caspase 3, 8, and 9 in tumoral tissues from patients with colorectal
cancer (CRC) and compare it with normal marginal tissues.
本研究旨在評估結直腸癌(CRC)患者腫瘤組織中Caspase 3,8和9的轉錄水平,
並與正常邊緣組織進行比較。
Experiments indicated that mRNA expressions of caspase 9 and 3 were
downregulated in tumoral tissues from CRC patients in comparison to
marginal tissues.
實驗表明,與邊緣組織相比,來自CRC患者的腫瘤組織中caspase 9和3的mRNA表達下調。
Moreover, immunohistochemistry analysis showed downregulation of caspase-7
and -9 in colon cancer samples compared with normal mucosa
此外,免疫組織化學分析顯示,與正常粘膜相比,結腸癌樣本中caspase-7和-9的下調
Caspase-2,-8,-9,-10是細胞凋亡的起始
Caspase-3,-6,-7則主要與細胞凋亡的最終執行有關
Caspase-1,-4,-5,-14組成,與細胞凋亡關係不是很密切,
主要與發炎信號的產生和免疫調節有關。
干擾素γ誘導caspases-1,-3,-8的上調產生細胞凋亡
caspase-1, -2, -6, -8, and -9mRNAs被IFNγ上調
IFN-γ直接誘導bak,Bak導致增強的caspase 7。
IL-4引起促凋亡蛋白Bax從細胞質轉移至線粒體,Bax的過量導致細胞通過caspase-3凋亡。
能提高IL-4的元素:
鋅、維生素A、兒茶素、茄紅素、薑黃素、黃酮類化合物
(蜂膠黃酮、生物類黃酮、大豆異黃酮)、鞣花酸
能提高IFN-γ的元素:
鋅、硒、錳、維生素C、高劑量維生素E、茄紅素
、大豆異黃酮、蜂膠黃酮、多醣體(葡萄糖靈芝王)
總結以上:
建議補充鎂鋅硒維他命ACE讓大腸癌細胞通過身體的機制死亡。
補充鎂鋅硒維他命ACE建議一天一粒男性/女性善存綜合維它命礦物質或一天兩罐草莓亞培安素或桂格特級完膳
含鋅高的食物(由多至少依序排列):
含維生素A高的食物:胡蘿蔔、甜椒、鴨蛋黃、鵝蛋黃、枸杞、綠花椰菜、綠茶
含鎂高的食物(由多至少依序排列):海苔、松子、榛果、亞麻籽、南瓜子、甘草、小茴香、桑葚
、芥末、核桃、黑芝麻、葵花籽、杏仁、蕎麥、菊花、黑豆(豆漿)
含維它命E高的食物【芝麻籽(黑)、核桃(干)[胡桃]、芝麻籽(白)、黃豆粉、桑葚(干)】