日誌
印戒細胞癌，怎麼治？(可能缺鎂、鋅)
印戒細胞癌患者
https://health.ndu(的相反).com/health/story/5999/3061094
印戒細胞癌（Signet ring cell carcinoma，SRCC），
又稱黏液細胞癌（mucinous cell carcinoma，MCC）
是上皮組織的惡性腫瘤
它是腺癌的一種表現形式，最常見於消化系統
腫瘤細胞胞質豐富、充滿黏液，核被擠壓於胞質一側呈“印戒”樣
幾種常見的印戒細胞癌
1.胃印戒細胞癌
2.乳腺印戒細胞癌
3.膀胱印戒細胞癌
4.前列腺印戒細胞癌
5.胰腺印戒細胞癌
signet-ring cell colorectal carcinoma (SRCC)
印戒細胞結直腸癌（SRCC）
SRCCs showed a significantly greater MMP-1 expression compared to
the ordinary intestinal colorectal cancer (ICRC)
and a significantly reduced E-cadherin, β-catenin and fibronectin expression.
與普通腸結腸直腸癌（ICRC）相比，SRCC顯示出顯著更高的MMP-1表達，
並且顯著降低的E-鈣粘蛋白，β-連環蛋白和纖連蛋白表達。
Conclusion: The biological aggressiveness and strong metastatic behaviour
of SRCC could be due to high MMP-1 and low expression of the adhesion molecules.
結論：SRCC的生物學侵襲性和強烈的轉移行為可能與MMP-1高表達和粘附分子表達低有關。
The expression rates of maspin, uPA and MMP-7 protein were 50%, 70% and 80%
in gastric adenocarcinoma, and 46.7%, 76.7%, and 90% in signet-ring cell carcinoma,
respectively.
maspin，uPA和MMP-7蛋白在胃腺癌中的表達率分別為50％，70％和80％，
印戒細胞癌中maspin，uPA和MMP-7蛋白的表達率分別為46.7％，76.7％和90％。
鋅抑制MMP介導的膠原降解
基質金屬蛋白酶通常通過內源性抑製劑保持平衡，金屬蛋白酶（TIMP-1）
IL-10刺激TIMP-1的產生。
能提高IL-10的元素：鋅
group pretreated with intravenous magnesium sulfate (0.27 mmol/kg)
(magnesium group, n = 19), and nonpretreated controls (placebo group).
靜脈注射硫酸鎂（0.27 mmol / kg）（鎂組，n = 19）和未預處理對照組（安慰劑組）。
The peak serum levels of interleukin-6 (IL-6) were significantly lower
in the magnesium group than those in the placebo group
(38.9 +/- 25.0 vs 92.3 +/- 76.5 pg/mL, p = 0.016).
鎂組的白細胞介素-6（IL-6）峰值血清水平顯著低於安慰劑組
The peak serum levels of matrix metalloproteinase-1 (MMP-1) were lower than
those in the placebo group (16.2 +/- 4.8 vs 19.7 +/- 9.0 ng/mL, p = 0.09),
but the difference was not significant.
基質金屬蛋白酶-1（MMP-1）峰值血清水平低於安慰劑組，但差異不顯著。
A positive correlation was observed between the peak MMP-1 values and
the peak IL-6 values (r = 0.57, p = 0.001) in all patients.
在所有患者中觀察到峰值MMP-1值與峰值IL-6值之間呈正相關。
能降低IL-6：鎂、鋅
The Avidity of Cell Surface αEβ7 Is Regulated
by removing calcium and elevating magnesium,
leads to increased adhesion to E-cadherin–Fc.
通過去除鈣和提高鎂，導致對E-鈣粘蛋白-Fc的粘附增加。
The downregulation of Wnt/β-catenin signaling pathway is associated with
zinc deficiency-induced proliferative deficit of C17.2 neural stem cells.
β-catenin信號通路的下調與缺鋅誘導的C17.2神經幹細胞的增殖缺陷相關。
總結以上：
印戒細胞癌可能缺鎂、鋅導致
建議用含鎂、鋅高的食物http://blog.eyny.com/blog-5788411-733718.html治療
而由於
幾種常見的印戒細胞癌
1.胃印戒細胞癌
2.乳腺印戒細胞癌
3.膀胱印戒細胞癌
4.前列腺印戒細胞癌
5.胰腺印戒細胞癌
因此或許
治療這些癌症不能缺
鎂、鋅
相關文章：
胰臟癌(胰腺癌、胰臟神經內分泌腫瘤)，怎麼治？Part-II(為什麼胰臟癌很難治？)
胰臟癌(胰腺癌、胰臟神經內分泌腫瘤)，怎麼治？
